Abstract: In order to solve the engineering problems of strict convergence condition of traditional decentralized algorithm and huge computation amount of centralized algorithm in vibration active control of complex systems， this paper combines network topology cooperation strategy and FxLMS algorithm to design a novel active vibration control algorithm based on network topology cooperation， and selects a simplified airframe model of a helicopter as the controlled object. The simulation study of active vibration control with a scale of 20×20 （20 actuators and 20 error sensors） is carried out. The results show that the algorithm based on network topology can achieve the same vibration reduction effect as the centralized algorithm while significantly reducing the computation amount， which is an advantage that the decentralized algorithm and the centralized algorithm do not have. The mean vibration decreases about 34.3 dB under single-frequency control， and about 12.6 dB under multi-frequency control. At the same time， the characteristics of secondary path coupling are properly simplified， which is conducive to the value of convergence coefficient， and the effectiveness and superiority of this algorithm for active vibration control of helicopter complex system are fully verified.