Abstract: To study the influence of the vibration characteristics of ballastless track on bridge under the failed fasteners， this thesis adopts an existing scale model of ballastless track-box girder structure. Under the random loading， the influence of different invalid fasteners conditions on the vibration response change of the track-box girder structure is discussed. The results show that the peak value of acceleration admittance increases and the peak frequency of admittance moves forward when the fastener fails， it appears in each component of the mid-span section of track-box girder structure， especially appears in the rail and track plate. At the same time， it is found that when the distance between the failure fastener and the observed section is different， the vibration response effect of the rail-box girder components is also different. When the distance between the failure fastener and the observed section within one fastener spacing， the acceleration admittance of each component of the track-box girder increases significantly， with the peak value at the track plate increasing by 1.48 times. When the distance between the failure fastener and the observed section is more than three fastener spacings， the acceleration response increase of each component of the box beam is within 5%. In addition， it is found that the dynamic response of various components of the track-box girder structure is directly proportional to the number of failed fasteners. For example， the peak acceleration admittance of the three fasteners with continuous failure at the track plate is 1.9 times higher than that without failure of fasteners. The maximum increase of peak admittance at the top plate and wing plate is 131% and 82% respectively， while the increase of peak admittance at the web plate and bottom plate of the box girder is approximately less than 25%.