Abstract: In order to explore the correlation between seated body pressure distribution and biomechanical loading， a setup scheme for the human-chair contact surface for human biomechanical modelling is proposed using body pressure information as a guide. The contact between the human body and the seat is simulated by a certain number of contact points， and based on the experimental body pressure distribution data， the relative contact strength is set as the relative magnitude of the average pressure in each partition of the body pressure cloud map. Through comparison， it is discovered that the average contact strength is set between 200~600， which can improve the solution accuracy and take into account the real muscle activation effect. At the same time， the scheme of different numbers of contact points was discussed， and it is more reasonable to choose to set 8 contact points in a comprehensive view. After comparing with the experimental data in the literature， it is shown that the contact scheme based on the body pressure distribution of the human chair biomechanical model can accurately reflect the muscle activation， joint force and other biomechanical indicators. Muscle activation and joint forces under hardwood planks and foam cushions were compared based on a contact scenario setup， explaining the reasons for more comfortable foam seating from a biomechanical point of view.