Abstract: In order to systematically study the seismic performance of shear walls and frame-shear wall structures under multi-dimensional earthquakes, three reinforced concrete shear wall specimens with a scale ratio of 1/2 and a reinforced concrete frame-shear wall specimen with a scale ratio of 1/3 were fabricated, and the quasi-static loading was carried out. In order to study the seismic performance of the shear wall specimens under different stress directions, they were subjected to the loading in the oblique, in-plane and out-of-plane directions, respectively. Due to the limitation of the loading site, only the frame-shear wall specimens are loaded in the in-plane direction. The characteristics of the macroscopic failure phenomenon, crack development, hysteresis curve, skeleton curve and stiffness degradation curve of the specimen were analyzed. Furthermore, a comprehensive damage index calculation equation is proposed that can accurately reveal the damage evolution process and final damage degree of shear wall components. On the basis of the calibration test, the finite element software is used to simulate and analyze the quasi-static loading of the shear wall and the frame shear wall structure from multiple angles, and the seismic performance and failure mode of the two types of structures under different loading angles are compared. The results show that the bearing capacity, energy dissipation capacity and lateral stiffness of the shear wall and frame shear wall structure decrease with the increasing loading angle, and the crack development and failure mode of the two types of structures will change under out-of-plane loading. It is urgent to analyze and improve the seismic performance of the two types of structures under multi-dimensional loading.