Abstract: The increase of train running speed and the wide use of light body technology make the vehicle system more sensitive to aerodynamic excitation. However, in addition to train running safety, few studies have paid attention to the deterioration of passenger riding comfort when trains pass along windy railway lines. Therefore, in this paper, combined with the rigid-flexible coupling model of human body-seat,-car body- track and the aerodynamic model of high-speed train, the effects of rigid and flexible vibration of the car body on the vibration response of human body when the train runs at different speeds under the crosswind are studied. The results show that the main frequency of most aerodynamic loads is close to the natural frequency of the train, which will affect the passenger riding comfort. When considering the flexible vibration of the car body under crosswinds, the vibration amplitude of all parts of the human body increases, indicating that only considering the rigid vibration of the car body will underestimate the discomfort of human body vibration. The flexible vibration of the car body has no obvious effect on the vibration of the human body in the low frequency band less than 7 Hz, but it will stimulate more high-frequency vibration.