Abstract: A RTHT framework based on LABVIEW-MATLAB-GPU is established，which uses graphics processor（GPU）instead of the traditional central processing unit（CPU）as the hardware for numerical solution. Taking a soil-structure interaction system as an example，the performance of the testing framework is verified through numerical simulation and RTHT testing. The testing and simulation results demonstrate that the proposed RTHT framework allows numerical substructure with 27000 DOFs to be solved in real time，hence that the application range of RTHT is expanded significantly by the calculation capacity of GPU.